Keywords:Purine salvage pathway, parasitic protozoa, Trypanosoma, Leishmania, Plasmodium, inhibitors, iminoribitols, nucleoside hydrolase. 82 terms. Extra hepatic tissues! Moreover, many analogues of purines and pyrimidines are used as chemotherapeutic agents that are introduced into the cell via the salvage pathways. AKA not the liver. The resulting mutants are viable under normal conditions but are hypersensitive to inhibition of purine nucleotide synthesis in their host cell. The nucleotide monophosphates (AMP, IMP and CMP) are converted to their … Purine Salvage is a biochemical pathway that recycles partially degraded purine bases to reform purine nucleotides. PNP is an enzyme in the purine salvage pathway that metabolizes inosine and guanosine to hypoxanthine. The net formation of purine nucleotides is performed by the de novo pathway, but rapid turnover of nucleic acids, especially RNA, is required for nucleotide production by the salvage pathways. PNP activity has been reported to a much lesser extent in heart and muscle. In general, the salvage pathway occurs in extrahepatic tissues. OTHER SETS BY THIS CREATOR. Expert Answer . Purines can be generated in the cells during the degradation of nucleic acids through salvage pathways. Turnover of nucleic acids (particularly RNA) in most cells releases adenine, guanine, and hypoxanthine. 37 terms. A salvage pathway is a pathway in which a biological product is produced from intermediates in the degradative pathway of its own or a similar substance. Purine nucleoside phosphorylase (PNP) is an enzyme in the nucleotide salvage pathway that occurs in many tissues, but appears to be highest in the liver in hepatocytes, Kupffer cells, and sinusoidal endothelial cells. MTC - 71 - Purine. In contrast, only a single pathway has been identified for C. parvum purine nucleotide salvage. Describe how bases are recycled using salvage pathway. The de novo synthesis of purine nucleotides requires a great deal of energy in the form of ATP. In plant cells, purine bases and nucleosides originate from the intercellular breakdown of nucleic acids and nucleotides, as well as other reactions which release purine bases and nucleosides. 66 terms. Biochemistry - Nucleotide Metabolism. These free purines are reconverted to their corresponding nucleotides through salvage pathways. The end product of purine metabolism in humans is uric acid. Mechanism of degradation: 1. What does the salvage pathway start? This can occur either at the level of the recruitment and/or signaling of specific nucleotide or nucleoside receptors or through genetic alterations in key steps of the purine salvage pathway. Explain. {ref4}{ref5}{ref6}{ref7} In the preceding step of the pathway, ADA … Where does the salvage pathway occur? ... MBC-52 Purine Metabolism. 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